nod in 1 Search Results


nlrs inhibitor nod in 1 ni1  (MedChemExpress)
93
MedChemExpress nlrs inhibitor nod in 1 ni1
Nlrs Inhibitor Nod In 1 Ni1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/nod+in+1/NOD-IN-1/ppr0584350-64-0-7
Average 93 stars, based on 1 article reviews
nlrs inhibitor nod in 1 ni1 - by Bioz Stars, 2026-09
93/100 stars
  Buy from Supplier
nod-in-1  (MuseChem Chemicals)
N/A
NOD-IN-1, also known as MDK19922, Compound 4, is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptor 1 (NOD1) and NOD2, with corresponding IC50 values of 5.74 μM and 6.45 μM, respectively.
   Buy from Supplier
nodin1  (Selleck Chemicals)
93
Selleck Chemicals nodin1
Stimulation of NP cells with S. aureus and C. acnes combined with inhibitors. In cell‐ELISA was used to measure phospho‐ ERK, JNK, p38 and NFkB. Cells in monolayer under hypoxia were left to attach overnight before treatment with the inhibitors for TLR2, <t>NODin1</t> and both combined for 24 h. Followed by the inhibition was treatment with 50 μg/mL PGN, S. aureus (MOI 0.01) and C. acnes (MOI 0.01) for 2 h in combination with the inhibitors. The different shades of blue represent the different donors ( N = 3 donors, n = 3 wells, (stats performed on n = 9)). All the measured concentrations were normalized to the non‐treated control. The No treatment graphs, show the different levels of phospho ERK, JNK, p38 and NFkB for cells only inhibited but not treated with a stimulant. No Inhibition shows treatment with PGN, S. aureus and C. acnes without inhibitors and TLR2, NODin1 and Combined Inhibition show the treatment combined with the inhibition. Statistical analysis was performed using Kruskal Wallis multiple comparison against the control group of each treatment ( p = 0.05).
Nodin1, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/nod+in+1/NOD-IN-1/pmc12621228-103-12-24
Average 93 stars, based on 1 article reviews
nodin1 - by Bioz Stars, 2026-09
93/100 stars
  Buy from Supplier
nod-in-1  (Biosynth Carbosynth)
N/A
   Buy from Supplier
nod-in-1  (TargetMol)
N/A
   Buy from Supplier
nod-in-1  (Aladdin Scientific Corporation)
N/A
InformationNOD-IN-1 NOD-IN-1 (MDK19922, Compound 4) is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptor 1 (NOD1) and NOD2 with IC50 of 5.74 μM and 6.45 μM, respectively.
   Buy from Supplier
nod in 1  (Cayman Chemical)
N/A
NOD IN 1
   Buy from Supplier

Image Search Results


Stimulation of NP cells with S. aureus and C. acnes combined with inhibitors. In cell‐ELISA was used to measure phospho‐ ERK, JNK, p38 and NFkB. Cells in monolayer under hypoxia were left to attach overnight before treatment with the inhibitors for TLR2, NODin1 and both combined for 24 h. Followed by the inhibition was treatment with 50 μg/mL PGN, S. aureus (MOI 0.01) and C. acnes (MOI 0.01) for 2 h in combination with the inhibitors. The different shades of blue represent the different donors ( N = 3 donors, n = 3 wells, (stats performed on n = 9)). All the measured concentrations were normalized to the non‐treated control. The No treatment graphs, show the different levels of phospho ERK, JNK, p38 and NFkB for cells only inhibited but not treated with a stimulant. No Inhibition shows treatment with PGN, S. aureus and C. acnes without inhibitors and TLR2, NODin1 and Combined Inhibition show the treatment combined with the inhibition. Statistical analysis was performed using Kruskal Wallis multiple comparison against the control group of each treatment ( p = 0.05).

Journal: JOR Spine

Article Title: Intracellular Detection of C. acnes and S. aureus in Non‐Herniated Human Intervertebral Discs: Implications for Catabolic Signaling Pathways

doi: 10.1002/jsp2.70139

Figure Lengend Snippet: Stimulation of NP cells with S. aureus and C. acnes combined with inhibitors. In cell‐ELISA was used to measure phospho‐ ERK, JNK, p38 and NFkB. Cells in monolayer under hypoxia were left to attach overnight before treatment with the inhibitors for TLR2, NODin1 and both combined for 24 h. Followed by the inhibition was treatment with 50 μg/mL PGN, S. aureus (MOI 0.01) and C. acnes (MOI 0.01) for 2 h in combination with the inhibitors. The different shades of blue represent the different donors ( N = 3 donors, n = 3 wells, (stats performed on n = 9)). All the measured concentrations were normalized to the non‐treated control. The No treatment graphs, show the different levels of phospho ERK, JNK, p38 and NFkB for cells only inhibited but not treated with a stimulant. No Inhibition shows treatment with PGN, S. aureus and C. acnes without inhibitors and TLR2, NODin1 and Combined Inhibition show the treatment combined with the inhibition. Statistical analysis was performed using Kruskal Wallis multiple comparison against the control group of each treatment ( p = 0.05).

Article Snippet: Cells were treated with the inhibitors for nucleotide oligomerisation domain in 1 (NODin1, 10 μM, Selleckechem, S0004), toll like receptor 2 (TLR2, 50 μM, Selleckchem, S6597) and a combination of the two for 24 h prior to treatment.

Techniques: In-Cell ELISA, Inhibition, Control, Comparison

Cytokine expression following treatment with PGN, S. aureus and C. acnes in the presence of inhibitors. Cells in monolayer were left to attach overnight in a low oxygen chamber before stimulating them with TLR2 inhibitor, NODin1 inhibitor and a combination of the inhibitors for 24 h. Following the stimulation period cells were exposed to 50 μg/mL PGN, S. aureus (MOI 0.01) or C. acnes (MOI 0.01, MOI 0.1) for 2 h followed by a PBS wash and the addition of fresh media supplemented with the inhibitors. The secretome was collected and a Luminex assay was performed. Concentrations of each cytokine are shown normalized to the non‐stimulated non‐treated control. Statistical analysis was not performed for C. acnes at an MOI 0.1 as the experiment was only performed in biological duplicates. Kruskal‐Wallis multiple comparison test was used to compare the treatments with the stimulation control ( p = 0.05). Different shades represent different donors ( N = 3 donors, n = 3 wells, (stats performed on n = 9)).

Journal: JOR Spine

Article Title: Intracellular Detection of C. acnes and S. aureus in Non‐Herniated Human Intervertebral Discs: Implications for Catabolic Signaling Pathways

doi: 10.1002/jsp2.70139

Figure Lengend Snippet: Cytokine expression following treatment with PGN, S. aureus and C. acnes in the presence of inhibitors. Cells in monolayer were left to attach overnight in a low oxygen chamber before stimulating them with TLR2 inhibitor, NODin1 inhibitor and a combination of the inhibitors for 24 h. Following the stimulation period cells were exposed to 50 μg/mL PGN, S. aureus (MOI 0.01) or C. acnes (MOI 0.01, MOI 0.1) for 2 h followed by a PBS wash and the addition of fresh media supplemented with the inhibitors. The secretome was collected and a Luminex assay was performed. Concentrations of each cytokine are shown normalized to the non‐stimulated non‐treated control. Statistical analysis was not performed for C. acnes at an MOI 0.1 as the experiment was only performed in biological duplicates. Kruskal‐Wallis multiple comparison test was used to compare the treatments with the stimulation control ( p = 0.05). Different shades represent different donors ( N = 3 donors, n = 3 wells, (stats performed on n = 9)).

Article Snippet: Cells were treated with the inhibitors for nucleotide oligomerisation domain in 1 (NODin1, 10 μM, Selleckechem, S0004), toll like receptor 2 (TLR2, 50 μM, Selleckchem, S6597) and a combination of the two for 24 h prior to treatment.

Techniques: Expressing, Luminex, Control, Comparison